In vivo safety of self-filling osmotic tissue expander

doi:10.3969/j.issn.2095-4344.2013.51.016

Abstract

Abstract:

BACKGROUND: The osmotic tissue expander is a self-filling device consisting of an osmotic active hydrogel which is made of vinylpyrrolidone and mehtylmethacrylate. It can absorb body fluids and swell up gradually after embedded.
OBJECTIVE: To explore the short-term and long-term regular patterns as well as histocompatibility of the osmotic tissue expander in vivo.
METHODS: A self-control design was carried out in Wistar rats by embedding the osmotic tissue expander and high-density polyethylene into each side of their spinal column subcutaneously. Wound healing, tissue expansion and inflammatory reaction were detected and compared at different periods after operation.
RESULTS AND CONCLUSION: All the wounds got primary healing. The device expanded fastest at week 1 after the implantation. After being enlarged to about nine times that of the initial size at week 4, the expander slowed down its swelling. It reached its ultimate volume at week 12 which was about 10 times as big as that of the initial one. Then it remained almost the same size until the end of our design. Pathological sections showed that the inflammatory reaction of osmotic-tissue-expander-group had no significant difference from that of the control group (P > 0.05). These findings suggest that osmotic tissue expander has a slow-lasting swelling ability and good histocompatibility.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: biocompatible materials, polyethylene, histocompatibility, silicone elastomers

CLC Number:

R318

Sun Chuan-wei, Wang Zhao-xu, Chen Hua-de, Zheng Shao-yi, Bian Hui-ning, Lai Wen . In vivo safety of self-filling osmotic tissue expander[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(51): 8881-8886.

Figures/Tables 4

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